iProtein provides access to Eidogen-Sertanty's Target Informatics Platform (TIP) - the world's first protein structure informatics system and knowledgebase enabling structural interrogation of the druggable genome.
TIP amplifies the rapidly expanding body of experimental protein structural information found in the Protein Data Bank (PDB) by generating high accuracy protein structural models across sequences found in Swiss-Prot, RefSeq, Ensembl, IPI, etc. TIP leverages protein structural information across family members and corresponding crystal structure templates using an algorithm that has been validated in several top pharmaceutical companies and academic research sites. As such, TIP contains the world’s largest repository of protein structures and models.
The TIP Database
The Target Informatics Platform's content includes high resolution protein structures with reliably annotated small molecule binding sites, including >200,000 chains and comparative models of human proteins, covering every major drug target family including proteases, kinases, phosphatases, phosphodiesterases, nuclear receptors, and GPCRs.
In addition to TIP's high quality structural annotation, it is the only database of its kind that stores all similarity relationships between every sequence, structure, and binding site, making it an incredibly powerful system for structural and comparative proteomics.
Welcome to iProtein – the proteome in the sky!